| DIRECTLOAD 1588096 · TMA880418 | Dollar Financial Group, Inc. | 36 Finance | Registered | 2014 |
| DIRECTA 1501747 · TMA829055 | an individual | 5 Pharmaceuticals10 Medical44 Medical | Registered | 2012 |
| DIRECTPAY 2113938 | Payment Source Inc. | 36 Finance42 Science | Pending | 2021 |
| DIRECTPLATE 2359530 | Xerion Materials Corp. | 9 Electronics | Pending | 2024 |
| DirectWall 2152625 · TMA1247983 | an individual | 9 Electronics | Registered | 2024 |
| DIRECTFLOW 1570124 · TMA917226 | Hewlett Packard Enterprise Development LP | 9 Electronics | Registered | 2015 |
| DIRECTGATE 1022103 · TMA588707 | CSTAR TECHNOLOGIES INC. | 9 Electronics | Registered | 2003 |
| DIRECTscan 2364059 | IMPLANT DIRECT SYBRON INTERNATIONAL LLC | 10 Medical | Pending | 2024 |
| DIRECTLINE 2308596 | ReBalance Health, Inc. | 1 Chemicals | Pending | 2024 |
| DIRECT4 2074462 · TMA1168434 | TOYOTA JIDOSHA KABUSHIKI KAISHA (also trading asTOYOTA MOTOR CORPORATION) | 12 Vehicles | Registered | 2023 |
| DIRECTME 1944473 · TMA1239144 | an individual | 9 Electronics | Registered | 2024 |
| DIRECT 1936815 · TMA1137826 | NUTRIAG LTD. | 1 Chemicals5 Pharmaceuticals | Registered | 2022 |
| DIRECTKEY 1725546 · TMA990934 | Carrier Corporation | 9 Electronics42 Science | Registered | 2018 |
| DIRECTOR 1529391 · TMA824235 | Thomas & Betts International, Inc. | 9 Electronics | Registered | 2012 |
| DIRECTBET 1520829 · TMA819617 | Caesars License Company, LLC | 41 Education | Registered | 2012 |
| DIRECT 1477013 · TMA845809 · design | an individual | 35 Advertising | Registered | 2013 |
| DirectRF 1467258 · TMA789719 | Siemens Healthcare GmbH | 10 Medical | Registered | 2011 |
| DIRECTCU 1437737 · TMA821732 | Canadian Credit Union Association Cooperative | 9 Electronics14 Jewellery16 Paper+7 | Registered | 2012 |
| DIRECTBUY 1146106 · TMA662089 | DirectBuy Operations, LLC | 35 Advertising | Registered | 2006 |
| DIRECTV 1008933 · TMA614919 | The DIRECTV Group, Inc. | 9 Electronics16 Paper25 Clothing+2 | Registered | 2004 |
| DIRECTOR 0891864 · TMA552437 | DDP Specialty Electronic Materials US, LLC | 37 Construction40 Treatment42 Science | Registered | 2001 |
| DIRECTOR 0875486 · TMA527698 | Adobe Inc. | 9 Electronics35 Advertising38 Telecommunications+2 | Registered | 2000 |
| DIRECTEL 0858591 · TMA500728 | Royal & Sun Alliance Insurance Company of Canada | 36 Finance | Registered | 1998 |
| DIRECT3D 0802568 · TMA470300 | Microsoft Corporation | 9 Electronics | Registered | 1997 |
| DIRECTX 0802567 · TMA489947 | Microsoft Corporation | 9 Electronics | Registered | 1998 |