| OPTEMX 1514332 · TMA870894 | Exactech, Inc. | 5 Pharmaceuticals | Registered | 2014 |
| OPTEM 0882688 · TMA622416 | EXCELITAS TECHNOLOGIES CORP. | 9 Electronics10 Medical | Registered | 2004 |
| OPTEM 0755583 · TMA449116 | OPTEM ENGINEERING INC. | 9 Electronics16 Paper41 Education+1 | Registered | 1995 |
| OPTEMA 0678952 · TMA427734 | Exxon Mobil Corporation | 17 Rubber | Registered | 1994 |
| OPTOMAP 1074284 · TMA647762 | OPTOS PLC | 10 Medical44 Medical | Registered | 2005 |
| Optime 2208243 · TMA1280840 | an individual | 6 Metal7 Machines26 Sewing | Registered | 2025 |
| OPTIMI 2051920 · TMA1217931 | Optimi Health Corp. | 1 Chemicals5 Pharmaceuticals30 Coffee+1 | Registered | 2024 |
| OPTIMA 2034994 · TMA1144634 · design | Optima Contracting Limited | 6 Metal19 Building20 Furniture+1 | Registered | 2022 |
| OPTUM 2032781 · TMA1158087 | BASF Coatings GmbH, a legal entity | 2 Paints | Registered | 2022 |
| OPTIMY 1904110 · TMA1084859 · design | Hitron Technologies Inc. | 42 Science | Registered | 2020 |
| OPTIMA 1894160 · TMA1072287 | Midea America Corp. | 7 Machines | Registered | 2020 |
| OPTEON 1773307 · TMA1026621 | The Chemours Company FC, LLC | 1 Chemicals | Registered | 2019 |
| OPTUM 1740210 · TMA979836 | Optum, Inc. | 35 Advertising36 Finance37 Construction+5 | Registered | 2017 |
| OPTUM 1740209 · TMA979845 · design | Optum, Inc. | 35 Advertising36 Finance37 Construction+5 | Registered | 2017 |
| OPTUM 1733420 · TMA973645 | CNH Industrial America LLC | 12 Vehicles | Registered | 2017 |
| OPTIMA 1713786 · TMA963120 | COMPRESSION TECHNOLOGY CORPORATION | 7 Machines35 Advertising37 Construction+2 | Registered | 2017 |
| OPTIME 1711780 · TMA1042215 | CENTRE HOSPITALIER UNIVERSITAIRE SAINTE-JUSTINE | 44 Medical | Registered | 2019 |
| OPTEIN 1634579 · TMA938403 | MGPI Processing, Inc., a Corporation of the State of Kansas | 1 Chemicals | Registered | 2016 |
| OPTIMA 1608516 · TMA955037 | SUNOCO OVERSEAS, INC. | 4 Oils | Registered | 2016 |
| OPTIMA 1590329 · TMA879120 | Beckman Coulter, Inc. | 9 Electronics | Registered | 2014 |
| OPTIMA 1578824 · TMA852451 | Master Plant-Prod Inc. | 1 Chemicals5 Pharmaceuticals | Registered | 2013 |
| OPTIMA 1546277 · TMA834779 · design | CPS Technology Holdings LLC | 9 Electronics | Registered | 2012 |
| OPTUM 1537884 · TMA887664 · design | Optum, Inc. | 16 Paper35 Advertising38 Telecommunications+4 | Registered | 2014 |
| OPTUM 1536751 · TMA886380 | Optum, Inc. | 16 Paper35 Advertising38 Telecommunications+4 | Registered | 2014 |
| OPTIMA 1531149 · TMA834780 | CPS Technology Holdings LLC | 9 Electronics | Registered | 2012 |