| SAMJECTION 2008844 · TMA1108335 | OTSUKA PHARMACEUTICAL CO. LTD. | 5 Pharmaceuticals | Registered | 2021 |
| SANACKEYS 2256187 · TMA1274711 | Atlas Goods Inc. | 29 Meat30 Coffee | Registered | 2024 |
| Sunqiss 2252345 · TMA1284667 | Xygenyx Inc. | 3 Cosmetics | Registered | 2025 |
| SENSAGLO 2246166 · TMA1263257 | Owner not listed | 1 Chemicals | Registered | 2024 |
| Scancycle 2229135 · TMA1255081 | 1000362823 ONTARIO CORPORATION | 40 Treatment | Registered | 2024 |
| SmokyJoy 2226198 · TMA1252585 | Chaozhou Jinrui Heng Trading Co.Ltd. | 34 Tobacco | Registered | 2024 |
| Singcock 2220535 · TMA1248491 | an individual | 25 Clothing | Registered | 2024 |
| SNOWGAZ 2220062 · TMA1253776 | CHARBONE HYDROGEN Corporation | 37 Construction | Registered | 2024 |
| SUNSEEKER 2217672 · TMA1284622 · design | Zhejiang Sunseeker Industrial Co. Ltd. | 7 Machines9 Electronics | Registered | 2025 |
| SUNKISS 2217338 · TMA1246697 · design | SUNKISS HEALTHCARE (ZHEJIANG) CO. LTD. | 10 Medical | Registered | 2024 |
| SENSAIZ 2215864 · TMA1280886 | Lucid Vision Labs, Inc. | 9 Electronics10 Medical | Registered | 2025 |
| SENSAIZ 2215863 · TMA1284620 · design | Lucid Vision Labs, Inc. | 9 Electronics10 Medical | Registered | 2025 |
| SUNJOYCO 2208700 · TMA1241622 | SUNJOY CO., LTD | 18 Leather | Registered | 2024 |
| SYNEXIS 2174625 · TMA1206631 · design | Synexis LLC | 11 Lighting37 Construction | Registered | 2023 |
| SKIMSEEK 2167407 · TMA1203185 | Neogen Corporation | 42 Science | Registered | 2023 |
| SOMASIGNAL 2167390 · TMA1245061 | SomaLogic Operating Co. Inc. | 44 Medical | Registered | 2024 |
| SENSIC 2163059 · TMA1212387 · design | Sensic Inc. | 9 Electronics | Registered | 2023 |
| SNOWCASE 2159855 · TMA1228888 | Snowflake Inc. | 35 Advertising42 Science | Registered | 2024 |
| SMOKISSIME 2148408 · TMA1217269 · design | RESTAURANTS PACINI INC. | 29 Meat43 Restaurants | Registered | 2024 |
| SMOKISSIME 2148406 · TMA1217268 | RESTAURANTS PACINI INC. | 29 Meat43 Restaurants | Registered | 2024 |
| SAMESIES 2143482 · TMA1136710 | WHAT DO YOU MEME LLC | 28 Toys | Registered | 2022 |
| SANSAGITTA 2141421 · TMA1244987 | Aethlon Medical, Inc. | 10 Medical42 Science44 Medical | Registered | 2024 |
| SensiEject 2138593 · TMA1232159 | Oskar Frech GmbH + Co. KG | 7 Machines9 Electronics | Registered | 2024 |
| SIMAGIC 2133264 · TMA1146391 | Shenzhen Sumo Technology Co. Ltd. | 7 Machines | Registered | 2022 |
| SIMAGIC 2133263 · TMA1146390 | Shenzhen Sumo Technology Co. Ltd. | 12 Vehicles | Registered | 2022 |