| SPONGIE 1660499 · TMA914197 · design | Kruger Products Inc. | 35 Advertising41 Education | Registered | 2015 |
| SPONGIE 1659932 · TMA918063 | Kruger Products Inc. | 35 Advertising41 Education | Registered | 2015 |
| SPONGIN 1394212 · TMA798493 | SPONGEZZ INC. | 3 Cosmetics21 Housewares | Registered | 2011 |
| SPHINGOKINE 1402954 · TMA750011 | Evonik Operations GmbH | 1 Chemicals | Registered | 2009 |
| SEVENQ 2261864 · TMA1283099 · design | Shenzhen Milemi E-Commerce Co. Ltd. | 28 Toys | Registered | 2025 |
| SHEEPPING 2260191 · TMA1279393 | Shenzhen Jiumai Technology Co. Ltd. | 27 Carpets | Registered | 2024 |
| SHEFFANESSEA 2258393 · TMA1276507 | an individual | 25 Clothing | Registered | 2024 |
| SPONSORTIPS 2258179 · TMA1277753 | Frito-Lay North America, Inc. | 30 Coffee | Registered | 2024 |
| SupMaka 2219069 · TMA1246905 | Zhongshan Makabaka Network Technology Co. Ltd. | 12 Vehicles | Registered | 2024 |
| SPHYNX 2218935 · TMA1248364 | Sunrise Medical (US) LLC | 12 Vehicles | Registered | 2024 |
| SOBANKABLE 2190840 · TMA1234668 | Caplink Mortgage Corporation | 36 Finance | Registered | 2024 |
| Sufang 2182691 · TMA1242530 | Nanjing Fangsu Network Technology Co., Ltd. | 8 Hand | Registered | 2024 |
| SOVONCARE 2173694 · TMA1224547 | Guangzhou You Le Bai Trade Co. Ltd. | 3 Cosmetics10 Medical | Registered | 2024 |
| SUPMAKIN 2172568 · TMA1222384 · design | NINGBO YIXI KITCHENWARE CO.LTD | 8 Hand21 Housewares | Registered | 2024 |
| SAPONIQX 2169990 · TMA1256272 | SaponiQx, Inc. | 5 Pharmaceuticals42 Science | Registered | 2024 |
| SupMusk 2167767 · TMA1214540 | an individual | 9 Electronics | Registered | 2023 |
| SKAVENGERZ 2163987 · TMA1278761 | SKAVENGERZ, INC. | 35 Advertising | Registered | 2024 |
| SVENCAST 2149458 · TMA1187833 | Digistore24 Inc. | 9 Electronics38 Telecommunications41 Education | Registered | 2023 |
| SOFANIC 2137093 · TMA1200176 | Hangzhou Chucheng Electronic Commerce Co. Ltd. | 25 Clothing | Registered | 2023 |
| SPANSPACE 2134111 · TMA1208579 · design | DELI GROUP CO. LTD. | 9 Electronics16 Paper20 Furniture | Registered | 2023 |
| Suvimuga 2127868 · TMA1190900 | an individual | 25 Clothing | Registered | 2023 |
| SpinnaWes 2120451 · TMA1185333 | an individual | 41 Education | Registered | 2023 |
| SPUNK 2117333 · TMA1184115 | an individual | 18 Leather25 Clothing27 Carpets+1 | Registered | 2023 |
| SUPMAGI 2110097 · TMA1179243 | Shenzhen Shuxinfeng Technology Co. Ltd. | 9 Electronics | Registered | 2023 |
| Sufaniq 2108647 · TMA1201363 | an individual | 24 Textiles | Registered | 2023 |