| SIMPLEXA 1470760 · TMA783699 | DIASORIN MOLECULAR LLC | 5 Pharmaceuticals9 Electronics10 Medical | Registered | 2010 |
| SimpleLAN 2183254 · TMA1231290 | 1429481 Ontario Inc.(does business as Pathway Communications) | 9 Electronics38 Telecommunications42 Science | Registered | 2024 |
| SIMPLEX 2116563 · TMA1222907 · design | an individual | 37 Construction | Registered | 2024 |
| SIMPLEX 2096048 · TMA1172664 | Simplex Services Inc. | 35 Advertising45 Legal | Registered | 2023 |
| SIMPLESYNC 2002797 · TMA1258873 | BOSE CORPORATION | 9 Electronics | Registered | 2024 |
| Simplex 1803404 · TMA1104125 | SKF Marine GmbH | 7 Machines12 Vehicles17 Rubber+3 | Registered | 2021 |
| SIMPLEX 1781532 · TMA1020924 | Leemark Spinnings Limited | 11 Lighting21 Housewares24 Textiles+1 | Registered | 2019 |
| SIMPLEWINS 1405961 · TMA768838 | Owner not shown | 5 Pharmaceuticals10 Medical41 Education+1 | Registered | 2010 |
| SIMPLEX 1051514 · TMA594364 | Convoy Supply Ltd. Distribution Convoy Ltée. | 19 Building | Registered | 2003 |
| SIMPLEX 1001181 · TMA651274 | Tyco Fire & Security GmbH | 37 Construction42 Science45 Legal | Registered | 2005 |
| SIMPLEXX 0899718 · TMA556110 | Owner not shown | 5 Pharmaceuticals | Registered | 2002 |
| SIMPLEX 0854324 · TMA513366 | M.S. BASADUR & ASSOCIATES INC. | 9 Electronics35 Advertising41 Education+1 | Registered | 1999 |
| SIMPLEX 0501447 · TMA286109 | Kaba Ilco Corp. | 6 Metal9 Electronics20 Furniture | Registered | 1983 |
| SIMPLEX 0490367 · TMA319261 | Howmedica Osteonics Corp. | 5 Pharmaceuticals | Registered | 1986 |
| SIMPLEX 0423815 · TMA241871 | Enerpac Tool Group Corp. | 7 Machines12 Vehicles19 Building | Registered | 1980 |
| SIMPLEX 0423619 · TMA240342 · design | SKF Marine GmbH | 4 Oils6 Metal7 Machines+5 | Registered | 1980 |
| SIMPLEX 0235085 · TMA106369 | SAF-HOLLAND, Inc. | 12 Vehicles | Registered | 1957 |
| SIMPLEX 0181552 · UCA17277 | ROTHMANS, BENSON & HEDGES INC. | 34 Tobacco | Registered | 1942 |
| SIMPLEX 0173387 · UCA10687 | Tyco Fire & Security GmbH | 6 Metal9 Electronics11 Lighting+2 | Registered | 1938 |
| Simpledad 2374099 | Fuzhou Feibao Network Technology Co. Ltd. | 20 Furniture | Pending | 2025 |
| SIMPLEX 2292979 | SimplexCC Ltd. | 9 Electronics35 Advertising36 Finance+6 | Pending | 2022 |
| SIMPLEX 2278872 | Simplex Manufacturing Co. | 9 Electronics12 Vehicles | Pending | 2023 |
| SIMPLERA 2131477 | an individual | 5 Pharmaceuticals | Pending | 2021 |
| SIMPLEHUMAN 1748110 · TMA1006658 | Simplehuman LLC | 20 Furniture | Registered | 2018 |
| SIMPLETREAD 1510918 · TMA817421 | Moulure Alexandria Moulding Inc. | 19 Building | Registered | 2012 |