| Simpurgo 1850025 · TMA1018236 | Simpurgo Maintenance Management Corp | 37 Construction | Registered | 2019 |
| SIMPURE 1836914 · TMA1074800 | Cargill, Incorporated | 30 Coffee | Registered | 2020 |
| SIMPURE 1807419 · TMA1052795 | SIMPURE IMP. & EXP. LIMITED | 25 Clothing35 Advertising42 Science | Registered | 2019 |
| SIMPARICA 1708638 · TMA981084 | Zoetis Services LLC | 5 Pharmaceuticals | Registered | 2017 |
| Simpring 1571758 · TMA875967 | Kabushiki Kaisha Buffalo, trading as Buffalo Inc. | 9 Electronics28 Toys | Registered | 2014 |
| SIMPORT 0846877 · TMA493111 · design | 3088081 CANADA INC. | 40 Treatment | Registered | 1998 |
| SIMPURE 2276800 · design | an individual | 7 Machines11 Lighting | Pending | 2023 |
| SIMPURE 2275052 | an individual | 7 Machines11 Lighting | Pending | 2023 |
| Semperit 2199052 | Owner not shown | 7 Machines9 Electronics10 Medical+7 | Pending | 2021 |
| SIMPRO 1802124 · TMA1030019 | an individual | 10 Medical | Registered | 2019 |
| SIMPROVE 1665088 · TMA1036023 | an individual | 9 Electronics42 Science | Registered | 2019 |
| SUMABRITE 0341680 · TMA182620 | Diversey, Inc. (a Delaware corporation) | 3 Cosmetics | Registered | 1972 |
| ShineBurky 2259575 · TMA1279341 | Shenzhen RuiQi Network Technology Co. Ltd | 11 Lighting | Registered | 2024 |
| SINOPHARM 2257453 · TMA1276338 · design | China Sinopharm Healthcare Industry Company | 3 Cosmetics5 Pharmaceuticals29 Meat+3 | Registered | 2024 |
| SnapFresh 2207655 · TMA1241530 | Ningbo Winbay Technology Co.,Ltd. | 7 Machines | Registered | 2024 |
| Sinipart 2200298 · TMA1237659 | Guangzhou Yvexiu mujia Trading Co., Ltd | 25 Clothing | Registered | 2024 |
| SKINFIRST 2182876 · TMA1230369 | The Gillette Company LLC | 8 Hand | Registered | 2024 |
| SANPRA 2174748 · TMA1268383 | NIPPON INSTRUMENTS CORPORATION | 9 Electronics | Registered | 2024 |
| Sinborn 2167836 · TMA1213535 | Shenzhen Huoshi Network Technology Co. Ltd. | 28 Toys | Registered | 2023 |
| SIEMPRE 2167614 · TMA1206594 | Siempre Spirits Limited | 33 Wine | Registered | 2023 |
| SOMNOPRESS 2159379 · TMA1218436 | VITAZAN HERBS & VITAMINS INC. | 5 Pharmaceuticals | Registered | 2024 |
| SEMPERLEX 2158776 · TMA1272471 | Owner not shown | 45 Legal | Registered | 2024 |
| SINOPARCEL 2144594 · TMA1201695 · design | Owner not shown | 11 Lighting | Registered | 2023 |
| SNAPWIRELESS 2143341 · TMA1183206 | SNAPWIRELESS PTY LTD | 9 Electronics | Registered | 2023 |
| SYMBRAVO 2141776 · TMA1184352 | Axsome Therapeutics, Inc. | 5 Pharmaceuticals | Registered | 2023 |