| softrail 2098167 · TMA1239424 | an individual | 10 Medical | Registered | 2024 |
| SOFTRAID 2064933 · TMA1133419 | New Concepts Development Corporation | 9 Electronics | Registered | 2022 |
| SOFTERRA 2081600 | KEDS, LLC | 25 Clothing | Pending | 2021 |
| SOFTEARL29 2025872 · TMA1265110 | Fine Cotton Factory Inc. | 9 Electronics10 Medical | Registered | 2024 |
| SPOTTERFUL 2300887 · design | Groupe Mouse at Work Inc. | 42 Science | Pending | 2023 |
| SOFTDROPS 2107786 · TMA1179168 | The Ddrops Company Inc. | 5 Pharmaceuticals | Registered | 2023 |
| SOFTRUN 2005042 · TMA1132689 | East Hope Enterprise Inc. | 24 Textiles25 Clothing27 Carpets | Registered | 2022 |
| SOFTWEIR 1914012 · TMA1091628 | SOFTWEIR INC. | 42 Science | Registered | 2021 |
| SOFTRIPE 1905200 · TMA1117053 · design | FRIGOTEC Kälte- und Verfahrenstechnik GmbH | 11 Lighting31 Fresh | Registered | 2022 |
| SOFTRIDE 1632800 · TMA897386 | Technical Drilling Tools, Ltd. | 7 Machines | Registered | 2015 |
| SPIDERFX 1367827 · TMA741824 | ev3 Endovascular, Inc. (a Delaware Corporation) | 10 Medical | Registered | 2009 |
| SOFTAIR 1240732 · TMA656842 | an individual | 28 Toys | Registered | 2006 |
| SOFTWAIR 1220667 · TMA678531 · design | AIRWAIR INTERNATIONAL LIMITED | 25 Clothing | Registered | 2006 |
| SOFTDRIVE 1215862 · TMA653181 | an individual | 7 Machines12 Vehicles | Registered | 2005 |
| SoftR 1182536 · TMA665158 | Owens Corning Intellectual Capital LLC | 17 Rubber | Registered | 2006 |
| SOFTRAK 1084564 · TMA570538 | SOFTRAK SYSTEMS INC. | 9 Electronics | Registered | 2002 |
| SOFTREND 1026425 · TMA552572 | Softrend Systems Inc. | 9 Electronics42 Science | Registered | 2001 |
| SOFTRON 0767625 · TMA447856 | SOFTRON COMPUTERS INC. | 35 Advertising | Registered | 1995 |
| SOFTRAC 0749058 · TMA440376 | THE GOODYEAR TIRE & RUBBER COMPANY (AN OHIO CORPORATION) | 12 Vehicles | Registered | 1995 |
| SOFTR 2350269 | Owner not listed | 9 Electronics42 Science | Pending | 2023 |
| SOFTROC 2070162 | 2712128 Ontario Inc. | 19 Building35 Advertising37 Construction | Pending | 2020 |
| SPOTHERO 2309122 · TMA1283547 | SpotHero, Inc. | 9 Electronics39 Transport42 Science | Registered | 2025 |
| SPYDER 2265957 · TMA1285019 | SPYDER ACTIVE SPORTS, INC. | 18 Leather20 Furniture21 Housewares | Registered | 2025 |
| SPEEDREVO 2225316 · TMA1241907 | Mizuno Corporation | 25 Clothing | Registered | 2024 |
| Seovediary 2223198 · TMA1248809 | Qingdao Mingyuanbo Electronics Co., Ltd | 9 Electronics | Registered | 2024 |