| SPONDIN 2169081 | Bhargava Phytolab Private Limited | 5 Pharmaceuticals | Pending | 2022 |
| SPANDEX 2022682 · TMA1190327 · design | Spandex Limited | 35 Advertising42 Science | Registered | 2023 |
| SPANDEX 2004165 · TMA1190306 · design | Spandex Limited | 35 Advertising42 Science | Registered | 2023 |
| SPANDEX 1739477 · TMA957289 | Hager & Werken GmbH & Co. KG | 10 Medical | Registered | 2016 |
| SPONTIN 0236830 · TMA106326 | BGP Pharma ULC | 5 Pharmaceuticals | Registered | 1957 |
| SPANDEX 2339162 · design | Spandex Limited | 35 Advertising42 Science | Pending | 2024 |
| SPANDAU 2184025 | SDS Imports, LLC | 13 Firearms35 Advertising | Pending | 2022 |
| SPAMEDICA 1273245 · TMA727602 | SpaMedica Infinite Vitality Clinic Yorkville Inc. | 3 Cosmetics | Registered | 2008 |
| SPAMEDICA 0857948 · TMA544196 | SpaMedica Infinite Vitality Clinic Yorkville Inc. | 35 Advertising44 Medical | Registered | 2001 |
| SPAMEDICA 0819128 · TMA503817 | SpaMedica Infinite Vitality Clinic Yorkville Inc. | 44 Medical | Registered | 1998 |
| SCUBANADIAN 1737316 · TMA1001510 · design | DRIVE-BY SHOOTING INC. | 6 Metal16 Paper18 Leather+4 | Registered | 2018 |
| SPENDVISION 1406329 · TMA818245 | VISA INTERNATIONAL SERVICE ASSOCIATION | 9 Electronics35 Advertising36 Finance+6 | Registered | 2012 |
| 9SEVENTY 2277530 · TMA1267548 | New Era Cap, LLC | 25 Clothing | Registered | 2024 |
| SPINDL 2251932 · TMA1270174 | Red Thread Innovations Inc. | 42 Science | Registered | 2024 |
| SoFound 2237844 · TMA1258255 | an individual | 9 Electronics35 Advertising42 Science | Registered | 2024 |
| SEVEN9THIRTEEN 2228953 · TMA1252862 | an individual | 14 Jewellery25 Clothing35 Advertising | Registered | 2024 |
| Skybender 2223278 · TMA1280905 | 9478-9450 Québec inc. | 8 Hand | Registered | 2025 |
| SAFANAD 2218163 · TMA1257887 | Safanad Limited | 36 Finance | Registered | 2024 |
| Spoontainable 2186592 · TMA1275870 | Spoontainable GmbH | 8 Hand30 Coffee | Registered | 2024 |
| SAFinity 2180414 · TMA1211343 | ROLLS-ROYCE plc | 9 Electronics35 Advertising | Registered | 2023 |
| SUPANOTCH 2179262 · TMA1275834 | an individual | 35 Advertising41 Education | Registered | 2024 |
| 2SEVENTYBIO 7 2179212 · TMA1239647 · design | 2seventy bio, Inc. | 5 Pharmaceuticals42 Science | Registered | 2024 |
| 2SEVENTYBIO 7 2176306 · TMA1239641 · design | 2seventy bio, Inc. | 5 Pharmaceuticals42 Science | Registered | 2024 |
| SAFANAD 2170299 · TMA1284366 · design | Safanad Limited | 36 Finance | Registered | 2025 |
| SWAPNOTE 2162431 · TMA1205419 | NINTENDO OF AMERICA INC. | 9 Electronics | Registered | 2023 |