| SPANSPACE 2134111 · TMA1208579 · design | DELI GROUP CO. LTD. | 9 Electronics16 Paper20 Furniture | Registered | 2023 |
| SPANXSCULPT 2368213 | Spanx, LLC | 25 Clothing | Pending | 2024 |
| SPANISH 21 0873609 · TMA538950 | MASQUE PUBLISHING, INC. (A COLORADO CORPORATION) | 9 Electronics35 Advertising41 Education | Registered | 2000 |
| SPANISH 21 0865442 · TMA525772 | MASQUE PUBLISHING, INC. (A COLORADO CORPORATION) | 28 Toys | Registered | 2000 |
| SPANSULE 0220099 · UCA45075 | GlaxoSmithKline Inc. | 5 Pharmaceuticals | Registered | 1953 |
| SPANSIVE 1976591 | Pi Inc. | 9 Electronics35 Advertising42 Science | Pending | 2019 |
| SPANXSMOOTH 2368208 | Spanx, LLC | 25 Clothing | Pending | 2024 |
| SPINSPINSHARE 2257009 | CFA Properties, Inc. | 28 Toys | Pending | 2023 |
| SEVENQ 2261864 · TMA1283099 · design | Shenzhen Milemi E-Commerce Co. Ltd. | 28 Toys | Registered | 2025 |
| SHEEPPING 2260191 · TMA1279393 | Shenzhen Jiumai Technology Co. Ltd. | 27 Carpets | Registered | 2024 |
| SHEFFANESSEA 2258393 · TMA1276507 | an individual | 25 Clothing | Registered | 2024 |
| SPONSORTIPS 2258179 · TMA1277753 | Frito-Lay North America, Inc. | 30 Coffee | Registered | 2024 |
| SupMaka 2219069 · TMA1246905 | Zhongshan Makabaka Network Technology Co. Ltd. | 12 Vehicles | Registered | 2024 |
| SPHYNX 2218935 · TMA1248364 | Sunrise Medical (US) LLC | 12 Vehicles | Registered | 2024 |
| SOBANKABLE 2190840 · TMA1234668 | Caplink Mortgage Corporation | 36 Finance | Registered | 2024 |
| Sufang 2182691 · TMA1242530 | Nanjing Fangsu Network Technology Co., Ltd. | 8 Hand | Registered | 2024 |
| SOVONCARE 2173694 · TMA1224547 | Guangzhou You Le Bai Trade Co. Ltd. | 3 Cosmetics10 Medical | Registered | 2024 |
| SUPMAKIN 2172568 · TMA1222384 · design | NINGBO YIXI KITCHENWARE CO.LTD | 8 Hand21 Housewares | Registered | 2024 |
| SAPONIQX 2169990 · TMA1256272 | SaponiQx, Inc. | 5 Pharmaceuticals42 Science | Registered | 2024 |
| SupMusk 2167767 · TMA1214540 | an individual | 9 Electronics | Registered | 2023 |
| SKAVENGERZ 2163987 · TMA1278761 | SKAVENGERZ, INC. | 35 Advertising | Registered | 2024 |
| SVENCAST 2149458 · TMA1187833 | Digistore24 Inc. | 9 Electronics38 Telecommunications41 Education | Registered | 2023 |
| SOFANIC 2137093 · TMA1200176 | Hangzhou Chucheng Electronic Commerce Co. Ltd. | 25 Clothing | Registered | 2023 |
| Suvimuga 2127868 · TMA1190900 | an individual | 25 Clothing | Registered | 2023 |
| SpinnaWes 2120451 · TMA1185333 | an individual | 41 Education | Registered | 2023 |