| SPADES 2108982 · TMA1191840 | Acecard Food Group Ltd. | 29 Meat | Registered | 2023 |
| SPATOGO 1380070 · TMA756787 | an individual | 44 Medical | Registered | 2010 |
| SOFTOES 2067595 | DJO, LLC | 10 Medical | Pending | 2020 |
| SPOTSEE 1883110 · TMA1124007 | ShockWatch, Inc. | 9 Electronics42 Science | Registered | 2022 |
| SPETEC 1828799 · TMA1055708 | an individual | 1 Chemicals17 Rubber | Registered | 2019 |
| SEPTDES 1789728 · TMA1037211 | Hagleitner Hygiene International GmbH | 5 Pharmaceuticals | Registered | 2019 |
| SPAWTS 1617069 · TMA891904 · design | an individual | 6 Metal16 Paper19 Building+4 | Registered | 2014 |
| SPAWTS 1617068 · TMA891901 | an individual | 6 Metal16 Paper19 Building+4 | Registered | 2014 |
| SPITS 1548140 · TMA875185 | Windsor Spitfires Inc. | 9 Electronics16 Paper21 Housewares+4 | Registered | 2014 |
| SPETEK 1464233 · TMA823056 | an individual | 9 Electronics | Registered | 2012 |
| SPYTEK 1220731 · TMA643337 | Produits Pylex ( 9046 7366 Québec inc. ) | 6 Metal | Registered | 2005 |
| SPUTTEK 1021881 · TMA552227 | Sputtek Inc. | 7 Machines40 Treatment | Registered | 2001 |
| SPUTEC 2357684 · design | JiuJiang Lida Technology Co. Ltd. | 17 Rubber | Pending | 2024 |
| SVETOSS 2259412 | BIOMATCAN LTD | 10 Medical | Pending | 2023 |
| SPITZEN 2018939 · design | Spitzen Cleaning Ltd. (Incorporation Number BC1106963) | 3 Cosmetics37 Construction | Pending | 2020 |
| SPOTKEY 1999751 | Spotkey, Inc. c/o Corporation Service Company | 9 Electronics39 Transport42 Science | Pending | 2019 |
| SEABODIES 1122032 · TMA597189 | Seabodies International Inc. | 9 Electronics25 Clothing28 Toys | Registered | 2003 |
| SCOPETTES 0280684 · TMA138296 | BIRCHWOOD LABORATORIES LLC | 5 Pharmaceuticals | Registered | 1964 |
| SYBTSP 2253507 · TMA1274413 | Quanzhou Fulingxiang E-commerce Co. Ltd | 25 Clothing | Registered | 2024 |
| SOFTEK 2247719 · TMA1257065 | SOCIÉTÉ HUMANFASHIONATION INC. | 25 Clothing | Registered | 2024 |
| SUPTEC 2244490 · TMA1263172 | Owner not listed | 25 Clothing | Registered | 2024 |
| SWIFTSURE 2224465 · TMA1250057 | Swiftsure Innovations Inc. | 10 Medical42 Science | Registered | 2024 |
| SPEEDCYLINDER 2221134 · TMA1239006 | Universal Engraving, Inc. | 7 Machines | Registered | 2024 |
| SAFETOUCH 2216615 · TMA1272694 | AMD Medicom Inc. | 10 Medical | Registered | 2024 |
| SPEEDSOFT 2209405 · TMA1242878 | TAYLOR MADE GOLF COMPANY, INC. | 28 Toys | Registered | 2024 |