| SPECLAR 1812758 · TMA1008783 | ContiTech USA, Inc. | 17 Rubber | Registered | 2018 |
| SEBIACLEAR 1748126 · TMA1005633 | an individual | 3 Cosmetics | Registered | 2018 |
| SWAPCLEAR 1454647 · TMA851992 | LCH LIMITED | 9 Electronics35 Advertising36 Finance+1 | Registered | 2013 |
| SAFECLEAR 1200906 · TMA629239 | FISHER SCIENTIFIC COMPANY L.L.C. | 5 Pharmaceuticals | Registered | 2005 |
| SPACELEAD 2311308 | an individual | 12 Vehicles20 Furniture | Pending | 2024 |
| SPEECHLESS 1823254 · TMA1011356 · design | Swat.Fame, Inc. | 25 Clothing | Registered | 2018 |
| SPEECHLESS 1345621 · TMA782491 | Swat.Fame, Inc. | 25 Clothing | Registered | 2010 |
| SPEAKLECTUAL 1859951 · TMA1040904 | Your Voice Unleashed Incorporated | 9 Electronics16 Paper35 Advertising+3 | Registered | 2019 |
| SPECLITE 1954916 · TMA1231920 · design | Speclite Technologies Inc. | 11 Lighting | Registered | 2024 |
| SAFECLEAN 1635959 · TMA908880 | Aspen Surgical Products, Inc. a Michigan corporation | 21 Housewares | Registered | 2015 |
| SAFECLEAN 0708337 · TMA432690 | Nilfisk, Inc. | 3 Cosmetics | Registered | 1994 |
| SPACKLE 0213365 · UCA41913 | ICP Construction, Inc. | 12 Vehicles19 Building | Registered | 1951 |
| SPÉCIAL 2305220 | Owner not shown | 9 Electronics28 Toys | Pending | 2024 |
| Speckle 2051610 | AEC SYSTEMS LTD | 9 Electronics35 Advertising38 Telecommunications+1 | Pending | 2020 |
| SPEAKWELL 2021253 | an individual | 35 Advertising41 Education | Pending | 2020 |
| SPACIAL 2006226 | 9338-9666 Québec Inc. | 9 Electronics35 Advertising36 Finance+2 | Pending | 2020 |
| SPACELAB 0971533 | THE EUROPEAN SPACE AGENCY | 1 Chemicals2 Paints3 Cosmetics+42 | Pending | 1997 |
| SAFESEAL 2245536 · TMA1269934 | AMD Medicom Inc. | 16 Paper | Registered | 2024 |
| SPIEGELAU 2198086 · TMA1259540 · design | G.J. Riedel GmbH | 21 Housewares | Registered | 2024 |
| SAPASLIFE 2191562 · TMA1233848 | an individual | 28 Toys | Registered | 2024 |
| SPECIALIZED 2185046 · TMA1213646 | Specialized Bicycle Components, Inc. | 12 Vehicles18 Leather | Registered | 2023 |
| SPICOLI 2168063 · TMA1166165 | Vans, Inc. | 9 Electronics | Registered | 2023 |
| SPEECHLY 2120861 · TMA1214134 | an individual | 9 Electronics42 Science | Registered | 2023 |
| SHAPESCALE 2120356 · TMA1191988 | Shape Labs, Inc. | 9 Electronics10 Medical | Registered | 2023 |
| SPECIALIZED 2108352 · TMA1211867 | Specialized Bicycle Components, Inc. | 9 Electronics35 Advertising41 Education+1 | Registered | 2023 |