| SPACELIFT 2106438 · TMA1277252 | Spacelift, Inc. | 42 Science | Registered | 2024 |
| SPACELIST 1670099 · TMA932032 | Spacelist Commercial Listings Ltd. | 35 Advertising36 Finance38 Telecommunications+1 | Registered | 2016 |
| SPECIALIST 1531650 · TMA835585 · design | WD-40 Manufacturing Company | 2 Paints3 Cosmetics4 Oils | Registered | 2012 |
| SPACELOFT 1484138 · TMA826684 | Aspen Aerogels, Inc. | 17 Rubber | Registered | 2012 |
| SPECILIFT 1397811 · TMA755820 | an individual | 3 Cosmetics | Registered | 2009 |
| SPECIALIST 1217983 · TMA646517 | Sakura Color Products Corporation | 16 Paper | Registered | 2005 |
| SPECIALYST 1049633 · TMA556145 | Evonik Operations GmbH | 1 Chemicals | Registered | 2002 |
| SPECIALIST 0850792 · TMA533340 | Owner not shown | 3 Cosmetics5 Pharmaceuticals7 Machines+12 | Registered | 2000 |
| SPECSHIELD 0835616 · TMA488632 | Linde GmbH | 1 Chemicals4 Oils | Registered | 1998 |
| SPECIALIST 0809444 · TMA489612 | FLEXOVIT USA, INC. | 7 Machines | Registered | 1998 |
| SPECIALIST 0195879 · UCA27625 | JOHNSON & JOHNSON (A NEW JERSEY CORPORATION) | 5 Pharmaceuticals10 Medical | Registered | 1947 |
| SPACELEAD 2311308 | an individual | 12 Vehicles20 Furniture | Pending | 2024 |
| SPECIALIST 2107492 | WD-40 Manufacturing Company | 2 Paints3 Cosmetics4 Oils | Pending | 2021 |
| Speckle 2051610 | AEC SYSTEMS LTD | 9 Electronics35 Advertising38 Telecommunications+1 | Pending | 2020 |
| SAFESEAL 2245536 · TMA1269934 | AMD Medicom Inc. | 16 Paper | Registered | 2024 |
| SPIEGELAU 2198086 · TMA1259540 · design | G.J. Riedel GmbH | 21 Housewares | Registered | 2024 |
| SAPASLIFE 2191562 · TMA1233848 | an individual | 28 Toys | Registered | 2024 |
| SPECIALIZED 2185046 · TMA1213646 | Specialized Bicycle Components, Inc. | 12 Vehicles18 Leather | Registered | 2023 |
| SPICOLI 2168063 · TMA1166165 | Vans, Inc. | 9 Electronics | Registered | 2023 |
| SPEECHLY 2120861 · TMA1214134 | an individual | 9 Electronics42 Science | Registered | 2023 |
| SHAPESCALE 2120356 · TMA1191988 | Shape Labs, Inc. | 9 Electronics10 Medical | Registered | 2023 |
| SPECIALIZED 2108352 · TMA1211867 | Specialized Bicycle Components, Inc. | 9 Electronics35 Advertising41 Education+1 | Registered | 2023 |
| Spesoul 2099371 · TMA1175798 | Quanzhou Zhongteng Network Technology Co.Ltd. | 25 Clothing | Registered | 2023 |
| SPICYLICIOUS 2097907 · TMA1209580 | JOLLIBEE FOODS CORPORATION | 29 Meat43 Restaurants | Registered | 2023 |
| SUAVEZILLA 2088271 · TMA1183885 · design | Xiamen Juxiu Decoration Engineering Co. Ltd. | 18 Leather | Registered | 2023 |