| SpiderMon 2183250 · TMA1230450 | 1429481 Ontario Inc.(does business as Pathway Communications) | 9 Electronics42 Science | Registered | 2024 |
| SpiderTie 2088992 · TMA1202645 | Karl Storz SE & Co. KG | 10 Medical16 Paper | Registered | 2023 |
| SpiderBond 2088991 · TMA1180372 | Karl Storz SE & Co. KG | 10 Medical16 Paper | Registered | 2023 |
| SPYDERCO 1993352 · TMA1119602 | Spyderco, Inc. | 18 Leather | Registered | 2022 |
| SPEEDROLL 1986542 · TMA1258751 | Saucony, Inc. | 25 Clothing | Registered | 2024 |
| SPIDERYO 1961570 · TMA1153614 | an individual | 28 Toys | Registered | 2022 |
| SPIDERWORT 1831226 · TMA1051256 · design | Spiderwort Inc. | 1 Chemicals5 Pharmaceuticals7 Machines+9 | Registered | 2019 |
| SpiderTrac 1783192 · TMA1008714 | Sunrise Medical (US) LLC | 12 Vehicles | Registered | 2018 |
| SPIDERTECH 1690310 · TMA920947 · design | Spidertech Inc. | 5 Pharmaceuticals35 Advertising40 Treatment+1 | Registered | 2015 |
| SPIDERTECH 1429688 · TMA763575 | Spidertech Inc. | 5 Pharmaceuticals35 Advertising41 Education | Registered | 2010 |
| SPIDERLOCK 0831605 · TMA483825 | Gestion Strada Inc. | 6 Metal | Registered | 1997 |
| SPYDERCO 0791109 · TMA468742 | SPYDERCO, INC. A COLORADO CORPORATION | 8 Hand | Registered | 1997 |
| SPIDERPLOW 2235079 | Innovative Trenching Solutions Ltd. | 37 Construction42 Science | Pending | 2023 |
| SPIDEROUT 2108924 | Premier Tech Ltée/Premier Tech Ltd. | 5 Pharmaceuticals21 Housewares | Pending | 2021 |
| SPYDERSHELL 1789449 · TMA1029854 | Air Locker, Inc. | 2 Paints6 Metal12 Vehicles+1 | Registered | 2019 |
| SPYDERWORKS 1304086 · TMA686725 | Spyder Works Inc. | 35 Advertising42 Science | Registered | 2007 |
| SPOTHERO 2309122 · TMA1283547 | SpotHero, Inc. | 9 Electronics39 Transport42 Science | Registered | 2025 |
| SPYDER 2265957 · TMA1285019 | SPYDER ACTIVE SPORTS, INC. | 18 Leather20 Furniture21 Housewares | Registered | 2025 |
| SPEEDREVO 2225316 · TMA1241907 | Mizuno Corporation | 25 Clothing | Registered | 2024 |
| Seovediary 2223198 · TMA1248809 | Qingdao Mingyuanbo Electronics Co., Ltd | 9 Electronics | Registered | 2024 |
| SPTRAMLE 2212448 · TMA1243115 · design | Shenzhen Xinchuang Garment Trading Co., Ltd. | 25 Clothing | Registered | 2024 |
| SAFEDROP 2199469 · TMA1223868 | Stericycle Inc. | 10 Medical40 Treatment | Registered | 2024 |
| SUPATRAZ 2177651 · TMA1245099 · design | Vita (Europe) Limited | 5 Pharmaceuticals | Registered | 2024 |
| SOFTERFIX 2171762 · TMA1201983 | an individual | 17 Rubber20 Furniture | Registered | 2023 |
| Saboteur 2145081 · TMA1257689 | AMIGO Spiel + Freizeit GmbH | 28 Toys | Registered | 2024 |