| SPECIFIX 1435464 · TMA772482 | Honeywell Safety Products USA, Inc. | 9 Electronics | Registered | 2010 |
| SPECIFIRE 1131678 · TMA602543 | Technical Glass Products, Inc. | 19 Building | Registered | 2004 |
| SpeechPad 0787141 · TMA506946 | Speech Processing Solutions GmbH | 9 Electronics16 Paper | Registered | 1999 |
| SPECIFY 2015094 · TMA1262404 | Improcrop U.S.A., Inc. | 1 Chemicals | Registered | 2024 |
| SPECFIL 1185487 · TMA621529 | The Dow Chemical Company | 1 Chemicals | Registered | 2004 |
| SPECFLEX 0614824 · TMA364224 | The Dow Chemical Company | 1 Chemicals | Registered | 1990 |
| SpecFlex 2267114 | Owner not listed | 11 Lighting | Pending | 2023 |
| SPECIIFX 2217809 | 2822084 Ontario Inc. | 9 Electronics16 Paper35 Advertising+3 | Pending | 2022 |
| SPECFIT 1985870 | Vallen Distribution, Inc. | 3 Cosmetics9 Electronics10 Medical+3 | Pending | 2019 |
| spaceforest 2259355 · TMA1277891 | Hunan Aijinmumu E-Commerce Co. Ltd. | 21 Housewares | Registered | 2024 |
| SPICEVIDS 2224826 · TMA1276008 | Owner not shown | 25 Clothing38 Telecommunications41 Education+1 | Registered | 2024 |
| SpoxFit 2194433 · TMA1235101 | an individual | 28 Toys | Registered | 2024 |
| SPYSAFE 2193833 · TMA1274184 | Spyscape Ltd | 38 Telecommunications | Registered | 2024 |
| Sovugavy 2179747 · TMA1228987 | an individual | 12 Vehicles | Registered | 2024 |
| SPACEFIT 2179703 · TMA1228977 · design | ATOP Solutions Inc. | 20 Furniture | Registered | 2024 |
| Savoychef 2172409 · TMA1143047 | Jetteo, LLC | 21 Housewares | Registered | 2022 |
| SPIKEVAX 2148047 · TMA1228862 · design | ModernaTX, Inc. | 5 Pharmaceuticals | Registered | 2024 |
| SFGB 2128788 · TMA1255618 | TJIKKO INTERNATIONAL HOLDINGS LTD. | 5 Pharmaceuticals29 Meat30 Coffee+3 | Registered | 2024 |
| SPIKEVAX 2109931 · TMA1127603 | ModernaTX, Inc. | 5 Pharmaceuticals | Registered | 2022 |
| SAFESPOTTER 2107295 · TMA1175909 | Smart Lite Technologies Ltd. | 11 Lighting12 Vehicles | Registered | 2023 |
| SVYAXFA 2089578 · TMA1168857 · design | an individual | 9 Electronics | Registered | 2023 |
| spaceblue 2059712 · TMA1154216 | an individual | 24 Textiles27 Carpets | Registered | 2022 |
| SPASOFT 2055251 · TMA1275447 · design | Gary Jonas Computing Ltd. | 9 Electronics42 Science | Registered | 2024 |
| SPEAKFLUENCE 2054126 · TMA1275421 | an individual | 9 Electronics41 Education | Registered | 2024 |
| SPEAKFREE 2053438 · TMA1128536 · design | Freudenberg Medical, LLC | 10 Medical | Registered | 2022 |