| SPIREON 1959666 · TMA1212617 · design | Spireon, Inc. | 42 Science | Registered | 2023 |
| SPIREON 1938431 · TMA1155891 | Spireon, Inc. | 9 Electronics42 Science | Registered | 2022 |
| SPIRONOSE 1788060 · TMA1025768 | Owner not shown | 9 Electronics10 Medical35 Advertising+2 | Registered | 2019 |
| SPIRION 1626843 · TMA1040870 | an individual | 9 Electronics10 Medical16 Paper+2 | Registered | 2019 |
| SPIRON 0498251 · TMA283727 | DANFOSS POWER SOLUTIONS II, LLC | 17 Rubber | Registered | 1983 |
| SPERONE 2332652 | an individual | 33 Wine | Pending | 2024 |
| SPIROMED 1989311 | Aerobit Health Inc | 10 Medical | Pending | 2019 |
| SUPERMONEY 0610711 · TMA365774 | LOBLAWS INC. | 16 Paper | Registered | 1990 |
| SPIREN 2190970 · TMA1234669 | an individual | 3 Cosmetics9 Electronics11 Lighting+2 | Registered | 2024 |
| spheroONE 2177447 · TMA1274122 | Scienion GmbH | 9 Electronics10 Medical42 Science | Registered | 2024 |
| SPIROMAX 2104898 · TMA1153294 | PATEK, PHILIPPE SA GENÈVE | 14 Jewellery | Registered | 2022 |
| Spormine 1982320 · TMA1124278 | Neksportek Corp. | 5 Pharmaceuticals | Registered | 2022 |
| SPERONI 1778621 · TMA991304 | an individual | 29 Meat | Registered | 2018 |
| SPERONI 1648013 · TMA920379 · design | an individual | 29 Meat | Registered | 2015 |
| SPRINGS 1406324 · TMA756579 · design | Springs of Living Water Centre Inc. | 41 Education | Registered | 2010 |
| SPIRENT 1066201 · TMA632074 · design | SPIRENT COMMUNICATIONS PLC | 1 Chemicals5 Pharmaceuticals6 Metal+14 | Registered | 2005 |
| SPIRENT 1066200 · TMA632867 | SPIRENT COMMUNICATIONS PLC | 1 Chemicals5 Pharmaceuticals6 Metal+13 | Registered | 2005 |
| SPRINGS 0759031 · TMA446696 | KEECO, LLC | 20 Furniture21 Housewares24 Textiles+1 | Registered | 1995 |
| SPRINGS 0546284 · TMA327391 | SPRING MANUFACTURERS INSTITUTE, INC. | 16 Paper | Registered | 1987 |
| SPHERON 0206843 · UCA36228 | CABOT CORPORATION (A DELAWARE CORPORATION) | 2 Paints | Registered | 1950 |
| SuperRunner 2323159 | Shenzhen Elighting Technology Co. Ltd | 18 Leather | Pending | 2024 |
| SUPRIM 2239479 · TMA1259936 · design | MICRO-STAR INT'L CO. LTD. | 9 Electronics | Registered | 2024 |
| SUPERHUMAN 2228785 · TMA1267010 | Superhuman Inc. | 5 Pharmaceuticals30 Coffee32 Beer | Registered | 2024 |
| Springbank 2222034 · TMA1253788 | Springbank Mechanical Systems Limited | 37 Construction | Registered | 2024 |
| SUPERMOON 2215736 · TMA1233985 | Audiolineout LLC | 9 Electronics | Registered | 2024 |