| STOPLESS 2071143 · TMA1284019 | Stopless Inc. | 9 Electronics42 Science | Registered | 2025 |
| StepLens 2032129 · TMA1268019 | Eclairage Axis Inc. | 11 Lighting | Registered | 2024 |
| STAPLES 1917629 · TMA1098563 · design | STAPLES, INC. | 2 Paints8 Hand9 Electronics+10 | Registered | 2021 |
| STAPLES 1800561 · TMA970261 | STAPLES, INC. | 8 Hand16 Paper21 Housewares+1 | Registered | 2017 |
| STAPLES 1778906 · TMA997886 | STAPLES, INC. | 1 Chemicals2 Paints3 Cosmetics+18 | Registered | 2018 |
| STAPLES 1297076 · TMA738255 · design | STAPLES, INC. | 35 Advertising | Registered | 2009 |
| STAPLES 1130202 · TMA570802 | STAPLES, INC. | 35 Advertising | Registered | 2002 |
| STAPLES 1004339 · TMA560480 · design | STAPLES, INC. | 9 Electronics16 Paper20 Furniture+2 | Registered | 2002 |
| STAPLES 0571290 · TMA372897 | STAPLES, INC. | 35 Advertising | Registered | 1990 |
| STAPLES 1957697 · design | STAPLES, INC. | 35 Advertising | Pending | 2019 |
| STOPaLOSS 2160871 | Retainagroup Limited | 16 Paper42 Science | Pending | 2022 |
| STEPLITE 1543249 · TMA851446 | an individual | 9 Electronics10 Medical25 Clothing | Registered | 2013 |
| STEAPLUS 1324031 · TMA767995 | an individual | 1 Chemicals16 Paper20 Furniture | Registered | 2010 |
| STEPWELL 1146742 · TMA578692 | an individual | 25 Clothing | Registered | 2003 |
| STAPLEX 0278712 · TMA136453 | an individual | 7 Machines10 Medical11 Lighting | Registered | 1964 |
| STEEPWELL 1826569 · TMA1009394 | PEAK DRIVE HOLDINGS LTD. | 30 Coffee | Registered | 2018 |
| STAPLEPAC 1558348 · TMA862958 | National Nail Corp. | 6 Metal | Registered | 2013 |
| STEEPLINE 2291769 · design | Owner not listed | 25 Clothing28 Toys | Pending | 2023 |
| STOWFLEX 2207588 · TMA1242760 | General Motors LLC | 12 Vehicles | Registered | 2024 |
| SKATEFLASH 2201112 · TMA1238637 · design | an individual | 12 Vehicles | Registered | 2024 |
| SUITEFLOW 2198095 · TMA1222510 | NetSuite Inc. | 42 Science | Registered | 2024 |
| STABILIZER 2151528 · TMA1206305 | Leachman Cattle of Colorado, LLC | 5 Pharmaceuticals31 Fresh | Registered | 2023 |
| STABILITY 2119865 · TMA1208461 | WILBUR-ELLIS COMPANY OF CANADA LIMITED | 1 Chemicals | Registered | 2023 |
| SWEATFLEECE 2109405 · TMA1277260 | Aritzia LP | 25 Clothing35 Advertising | Registered | 2024 |
| SWEETPLUCK 2107899 · TMA1177733 | an individual | 30 Coffee | Registered | 2023 |