| DIRECTLAB 1478826 · TMA797080 | Directlab Network Inc. | 9 Electronics40 Treatment | Registered | 2011 |
| DIRECTIONS 1613959 · TMA989469 | SERTA INC. | 20 Furniture | Registered | 2018 |
| DIRECTFLOW 1570124 · TMA917226 | Hewlett Packard Enterprise Development LP | 9 Electronics | Registered | 2015 |
| DIRECTOR 1529391 · TMA824235 | Thomas & Betts International, Inc. | 9 Electronics | Registered | 2012 |
| DIRECTA 1501747 · TMA829055 | an individual | 5 Pharmaceuticals10 Medical44 Medical | Registered | 2012 |
| DIRECTOR 0891864 · TMA552437 | DDP Specialty Electronic Materials US, LLC | 37 Construction40 Treatment42 Science | Registered | 2001 |
| DIRECTOR 0875486 · TMA527698 | Adobe Inc. | 9 Electronics35 Advertising38 Telecommunications+2 | Registered | 2000 |
| DIRECT3D 0802568 · TMA470300 | Microsoft Corporation | 9 Electronics | Registered | 1997 |
| DIRECTOR 0383469 · TMA211640 | Imperial Tobacco Products Limited | 34 Tobacco | Registered | 1976 |
| DIRECTscan 2364059 | IMPLANT DIRECT SYBRON INTERNATIONAL LLC | 10 Medical | Pending | 2024 |
| DIRECTLINE 2308596 | ReBalance Health, Inc. | 1 Chemicals | Pending | 2024 |
| DIRECTPAY 2113938 | Payment Source Inc. | 36 Finance42 Science | Pending | 2021 |
| DIRECTCOMMAND 1786758 · TMA999508 | Ag Leader Technology, Inc. | 9 Electronics | Registered | 2018 |
| DIRECTBOOKS 1996559 · TMA1255868 | DirectBooks Technologies LLC | 42 Science | Registered | 2024 |
| DIRECTTREND 1430082 · TMA765699 | an individual | 9 Electronics | Registered | 2010 |
| DIRECTTOUCH 1378068 · TMA829210 | Fresenius Medical Care Holdings, Inc. | 9 Electronics | Registered | 2012 |
| DIRECTSPEND 1323041 · TMA696133 | Blackhawk Network, Inc. (an Arizona corporation) | 35 Advertising36 Finance | Registered | 2007 |
| DirectSPARE 1130875 · TMA593152 | Körber Supply Chain Logistics GmbH | 7 Machines9 Electronics42 Science | Registered | 2003 |
| DIRECTPLATE 2359530 | Xerion Materials Corp. | 9 Electronics | Pending | 2024 |
| DirectGuide 2290844 | Owner not listed | 10 Medical | Pending | 2023 |
| DirectWall 2152625 · TMA1247983 | an individual | 9 Electronics | Registered | 2024 |
| DIRECT4 2074462 · TMA1168434 | TOYOTA JIDOSHA KABUSHIKI KAISHA (also trading asTOYOTA MOTOR CORPORATION) | 12 Vehicles | Registered | 2023 |
| DIRECTME 1944473 · TMA1239144 | an individual | 9 Electronics | Registered | 2024 |
| DIRECT 1936815 · TMA1137826 | NUTRIAG LTD. | 1 Chemicals5 Pharmaceuticals | Registered | 2022 |
| DirectView 1772266 · TMA1021253 | DMT Solutions Global Corporation, a Delaware corporation | 9 Electronics | Registered | 2019 |