| SEMIPACK 0413512 · TMA231301 | SEMIKRON Elektronik GmbH & Co. KG | 9 Electronics | Registered | 1978 |
| SEMIVAC 1614845 · TMA875820 | VACUUMSCHMELZE GMBH & CO. KG | 6 Metal | Registered | 2014 |
| SIMOVAC 1593504 · TMA909769 | an individual | 9 Electronics | Registered | 2015 |
| SimuPACT 2223228 | M-TECH INDUSTRIAL (PTY) LTD | 9 Electronics | Pending | 2022 |
| SIMPACT 1439045 · TMA763869 | SiMPACT STRATEGY GROUP INC. | 35 Advertising41 Education | Registered | 2010 |
| SINOPEC 1366295 · TMA726371 · design | CHINA PETROCHEMICAL CORPORATION | 1 Chemicals4 Oils17 Rubber+6 | Registered | 2008 |
| SOMUBAC 0785179 · TMA457453 | Zoetis Services LLC | 5 Pharmaceuticals | Registered | 1996 |
| SUNPAC 0533218 · TMA310389 · design | Sun Pac Foods Corp. | 29 Meat30 Coffee31 Fresh+1 | Registered | 1986 |
| SYMOPS 2259717 · design | Owner not listed | 9 Electronics35 Advertising38 Telecommunications+1 | Pending | 2022 |
| SINEPAC 2004492 | Sine-Energy Power Products Inc. | 9 Electronics | Pending | 2020 |
| SIMPAS 1964585 | AMVAC Chemical Corporation | 1 Chemicals5 Pharmaceuticals7 Machines+1 | Pending | 2019 |
| SEEMYPASS 2117442 | Marketucan Technologies Inc. | 35 Advertising | Pending | 2021 |
| SUNVKWEY 2261819 · TMA1281302 | Zhongshan Maixun Network Technology Co. LTD. | 11 Lighting | Registered | 2025 |
| Smofish 2250603 · TMA1268853 | Owner not listed | 9 Electronics20 Furniture | Registered | 2024 |
| SNIFFSCAPE 2239458 · TMA1259932 | an individual | 41 Education | Registered | 2024 |
| SOMMFACTORY 2234130 · TMA1256703 | an individual | 41 Education | Registered | 2024 |
| SMFK 2233787 · TMA1262864 · design | Yichen Fashion Design (Beijing) Co., Ltd. | 25 Clothing | Registered | 2024 |
| SMFK 2233785 · TMA1262863 · design | Yichen Fashion Design (Beijing) Co., Ltd. | 18 Leather | Registered | 2024 |
| SMFK 2233783 · TMA1262862 · design | Yichen Fashion Design (Beijing) Co., Ltd. | 14 Jewellery | Registered | 2024 |
| SYNOVACEPT 2232062 · TMA1250277 | Navidea Biopharmaceuticals, Inc. | 5 Pharmaceuticals | Registered | 2024 |
| SMPS 2227556 · TMA1252704 | SMPS Professional Services Corporation | 35 Advertising | Registered | 2024 |
| SAMBAZON 2218466 · TMA1237722 | Sambazon, Inc. | 29 Meat30 Coffee32 Beer+1 | Registered | 2024 |
| SAMPOCHEM 2203255 · TMA1280812 | SAMPOCHEM GmbH | 1 Chemicals | Registered | 2025 |
| Simabsie 2200326 · TMA1238574 | Shenzhen Jianan Trading Co. Ltd. | 21 Housewares | Registered | 2024 |
| SNAPPIES 2193012 · TMA1217651 | TYKABLES LLC | 25 Clothing | Registered | 2024 |