| SIMPLICAM 1708329 · TMA1025447 | SimpliSafe, Inc. | 9 Electronics | Registered | 2019 |
| SimpleTax 1589860 · TMA859479 | SIMPLETAX SOFTWARE INC. | 9 Electronics35 Advertising | Registered | 2013 |
| SIMPLYMAP 1465804 · TMA798748 | SimplyAnalytics, Inc | 35 Advertising36 Finance44 Medical | Registered | 2011 |
| SIMPLEMAT 1439278 · TMA767911 | Custom Building Products, Inc. | 27 Carpets | Registered | 2010 |
| SIMPLICA 1356244 · TMA725948 · design | Vatti Corporation Limited | 7 Machines11 Lighting | Registered | 2008 |
| SIMPLYLAX 2330539 | Owner not listed | 5 Pharmaceuticals | Pending | 2024 |
| simpliva 2251003 | Faisha Online Retail Limited | 20 Furniture | Pending | 2023 |
| SIMPLIMATIC 0596785 · TMA363682 · design | Simplimatic Engineering Holdings LLC | 7 Machines | Registered | 1989 |
| SIMPLIMATIC 0482218 · TMA298844 | Simplimatic Engineering Holdings LLC | 7 Machines | Registered | 1985 |
| SimplEmail 2183251 · TMA1230451 | 1429481 Ontario Inc.(does business as Pathway Communications) | 9 Electronics38 Telecommunications42 Science | Registered | 2024 |
| SIMPLISAFE 2104747 · TMA1219679 | SimpliSafe, Inc. | 9 Electronics11 Lighting42 Science | Registered | 2024 |
| SIMPLISAFE 1876815 · TMA1089165 · design | SimpliSafe, Inc. | 9 Electronics42 Science45 Legal | Registered | 2020 |
| SIMPLISAFE 1723172 · TMA1034585 | SimpliSafe, Inc. | 9 Electronics42 Science | Registered | 2019 |
| SIMPLINANO 1650995 · TMA952679 | Biochrom Limited | 9 Electronics | Registered | 2016 |
| SIMPLIFLEX 1037650 · TMA557785 | The Canada Life Assurance Company | 36 Finance | Registered | 2002 |
| SIMPLISAFE 2361834 · design | SimpliSafe, Inc. | 9 Electronics11 Lighting16 Paper+3 | Pending | 2024 |
| simplemark 2302750 | Hainan Sanlan Technology Holdings Co. Ltd. | 9 Electronics | Pending | 2023 |
| SIMPLEAT 2249017 · TMA1266010 | Owner not listed | 29 Meat | Registered | 2024 |
| Simpla 2188562 · TMA1232720 | Simpla Foods Inc. | 29 Meat30 Coffee | Registered | 2024 |
| SimpleLAN 2183254 · TMA1231290 | 1429481 Ontario Inc.(does business as Pathway Communications) | 9 Electronics38 Telecommunications42 Science | Registered | 2024 |
| SIMPLEAT 2168477 · TMA1245065 | Glanbia Nutritionals Limited | 1 Chemicals42 Science | Registered | 2024 |
| SIMPLIQ 2156438 · TMA1246295 · design | TOHATSU CORPORATION | 7 Machines9 Electronics | Registered | 2024 |
| SIMPLINK 2140879 · TMA1209757 · design | Owner not shown | 5 Pharmaceuticals10 Medical | Registered | 2023 |
| SIMPLELAB 2126437 · TMA1228799 | Simplelab, Inc. | 1 Chemicals42 Science | Registered | 2024 |
| SIMPLEX 2116563 · TMA1222907 · design | an individual | 37 Construction | Registered | 2024 |