| SPACELOOP 2132126 | an individual | 9 Electronics38 Telecommunications | Pending | 2021 |
| SPACELAB 0971533 | THE EUROPEAN SPACE AGENCY | 1 Chemicals2 Paints3 Cosmetics+42 | Pending | 1997 |
| SPACELOGIC 1950688 · TMA1250475 | SCHNEIDER ELECTRIC BUILDINGS LLC | 9 Electronics11 Lighting | Registered | 2024 |
| SPACELOGIC 1658217 · TMA1029513 | Stor-Med Pty Ltd. | 6 Metal7 Machines12 Vehicles+4 | Registered | 2019 |
| SPACELOFT 1484138 · TMA826684 | Aspen Aerogels, Inc. | 17 Rubber | Registered | 2012 |
| SPACELLS 1191943 · TMA656006 | Supracor, Inc. (a corporation of California) | 21 Housewares | Registered | 2006 |
| SPACELABS 0530877 · TMA309559 | Spacelabs Holdings, Inc. | 9 Electronics10 Medical | Registered | 1985 |
| SPACELEAD 2311308 | an individual | 12 Vehicles20 Furniture | Pending | 2024 |
| SAFESEAL 2245536 · TMA1269934 | AMD Medicom Inc. | 16 Paper | Registered | 2024 |
| SPIEGELAU 2198086 · TMA1259540 · design | G.J. Riedel GmbH | 21 Housewares | Registered | 2024 |
| SAPASLIFE 2191562 · TMA1233848 | an individual | 28 Toys | Registered | 2024 |
| SPECIALIZED 2185046 · TMA1213646 | Specialized Bicycle Components, Inc. | 12 Vehicles18 Leather | Registered | 2023 |
| SPICOLI 2168063 · TMA1166165 | Vans, Inc. | 9 Electronics | Registered | 2023 |
| SPEECHLY 2120861 · TMA1214134 | an individual | 9 Electronics42 Science | Registered | 2023 |
| SHAPESCALE 2120356 · TMA1191988 | Shape Labs, Inc. | 9 Electronics10 Medical | Registered | 2023 |
| SPECIALIZED 2108352 · TMA1211867 | Specialized Bicycle Components, Inc. | 9 Electronics35 Advertising41 Education+1 | Registered | 2023 |
| SPACELIFT 2106438 · TMA1277252 | Spacelift, Inc. | 42 Science | Registered | 2024 |
| Spesoul 2099371 · TMA1175798 | Quanzhou Zhongteng Network Technology Co.Ltd. | 25 Clothing | Registered | 2023 |
| SPICYLICIOUS 2097907 · TMA1209580 | JOLLIBEE FOODS CORPORATION | 29 Meat43 Restaurants | Registered | 2023 |
| SUAVEZILLA 2088271 · TMA1183885 · design | Xiamen Juxiu Decoration Engineering Co. Ltd. | 18 Leather | Registered | 2023 |
| (SAFEGOAL) 2085731 · TMA1278593 · design | an individual | 28 Toys35 Advertising | Registered | 2024 |
| SPEACLEAR 2065653 · TMA1226731 | Nemita Inc. | 9 Electronics | Registered | 2024 |
| SAFESHIELD 2039821 · TMA1165430 · design | The Trend Innovations Company Inc. | 5 Pharmaceuticals9 Electronics19 Building | Registered | 2023 |
| sofslee 2028576 · TMA1134966 | Zuo Jun Technology (Shenzhen) Co. Ltd. | 20 Furniture | Registered | 2022 |
| SEPIGEL 2025519 · TMA1163184 | an individual | 1 Chemicals | Registered | 2023 |