| SPECIFY 2015094 · TMA1262404 | Improcrop U.S.A., Inc. | 1 Chemicals | Registered | 2024 |
| SPECFLOR 1450542 · TMA787419 | Specialty Manufacturing, Inc. a corporation of Delaware | 19 Building | Registered | 2011 |
| SPECIFIX 1435464 · TMA772482 | Honeywell Safety Products USA, Inc. | 9 Electronics | Registered | 2010 |
| SPECFIL 1185487 · TMA621529 | The Dow Chemical Company | 1 Chemicals | Registered | 2004 |
| SPECIFIRE 1131678 · TMA602543 | Technical Glass Products, Inc. | 19 Building | Registered | 2004 |
| spaceforest 2259355 · TMA1277891 | Hunan Aijinmumu E-Commerce Co. Ltd. | 21 Housewares | Registered | 2024 |
| SPICEVIDS 2224826 · TMA1276008 | Owner not shown | 25 Clothing38 Telecommunications41 Education+1 | Registered | 2024 |
| SpoxFit 2194433 · TMA1235101 | an individual | 28 Toys | Registered | 2024 |
| SPYSAFE 2193833 · TMA1274184 | Spyscape Ltd | 38 Telecommunications | Registered | 2024 |
| Sovugavy 2179747 · TMA1228987 | an individual | 12 Vehicles | Registered | 2024 |
| SPACEFIT 2179703 · TMA1228977 · design | ATOP Solutions Inc. | 20 Furniture | Registered | 2024 |
| Savoychef 2172409 · TMA1143047 | Jetteo, LLC | 21 Housewares | Registered | 2022 |
| SPIKEVAX 2148047 · TMA1228862 · design | ModernaTX, Inc. | 5 Pharmaceuticals | Registered | 2024 |
| SFGB 2128788 · TMA1255618 | TJIKKO INTERNATIONAL HOLDINGS LTD. | 5 Pharmaceuticals29 Meat30 Coffee+3 | Registered | 2024 |
| SPIKEVAX 2109931 · TMA1127603 | ModernaTX, Inc. | 5 Pharmaceuticals | Registered | 2022 |
| SAFESPOTTER 2107295 · TMA1175909 | Smart Lite Technologies Ltd. | 11 Lighting12 Vehicles | Registered | 2023 |
| SVYAXFA 2089578 · TMA1168857 · design | an individual | 9 Electronics | Registered | 2023 |
| spaceblue 2059712 · TMA1154216 | an individual | 24 Textiles27 Carpets | Registered | 2022 |
| SPASOFT 2055251 · TMA1275447 · design | Gary Jonas Computing Ltd. | 9 Electronics42 Science | Registered | 2024 |
| SPEAKFLUENCE 2054126 · TMA1275421 | an individual | 9 Electronics41 Education | Registered | 2024 |
| SPEAKFREE 2053438 · TMA1128536 · design | Freudenberg Medical, LLC | 10 Medical | Registered | 2022 |
| SPACE2POP 2046586 · TMA1165630 | SPACE2POP LIMITED | 35 Advertising | Registered | 2023 |
| SABOSPORTS 2028051 · TMA1162023 | an individual | 25 Clothing28 Toys | Registered | 2023 |
| SPEXPRESS 2025777 · TMA1181200 · design | Shopper+ Inc. | 39 Transport | Registered | 2023 |
| SPIKEBRITE 2025532 · TMA1127419 | Kankakee Spikeball, Inc. | 28 Toys | Registered | 2022 |