| SPRED 0183586 · UCA18726 | PPG Architectural Finishes, Inc. | 2 Paints | Registered | 1944 |
| SPREAD 1611166 · TMA1072480 | Spread Media, Inc. | 9 Electronics35 Advertising38 Telecommunications+2 | Registered | 2020 |
| SPREAD 1559056 · TMA973904 | Spread Media, Inc. | 9 Electronics | Registered | 2017 |
| SPREED 1334523 · TMA783700 | Spreed Inc. | 9 Electronics | Registered | 2010 |
| SphereDx 2308679 | Digital Diagnostics Inc. | 42 Science | Pending | 2024 |
| SUPRADO 2069567 · TMA1210537 | ADAMA MAKHTESHIM LTD. | 5 Pharmaceuticals | Registered | 2023 |
| SUPRADO 1945206 · TMA1153547 | HANGERLOGIC INC. | 20 Furniture | Registered | 2022 |
| SUPREAD 1914523 · TMA1112522 | Elementis Specialties, Inc. | 1 Chemicals2 Paints | Registered | 2021 |
| SPORTEA 1239352 · TMA670603 | Ultimate Performance Products, Inc. | 30 Coffee | Registered | 2006 |
| SPORTEA 1239351 · TMA672934 · design | Ultimate Performance Products, Inc. | 30 Coffee | Registered | 2006 |
| SPORTEA 1239350 · TMA661426 · design | Ultimate Performance Products, Inc. | 30 Coffee | Registered | 2006 |
| Supered 2367106 | Canada Super Pharmaceutical CO. LTD. | 5 Pharmaceuticals35 Advertising | Pending | 2024 |
| SPRIDER 2266268 · design | an individual | 7 Machines | Pending | 2023 |
| SPRIDER 2266267 | an individual | 7 Machines | Pending | 2023 |
| SPAREDENT 2157222 · TMA1252245 | Sparedent GmbH | 7 Machines10 Medical | Registered | 2024 |
| SPORTPESA 1895745 · TMA1125435 | Sportpesa Holdings Limited | 3 Cosmetics9 Electronics16 Paper+9 | Registered | 2022 |
| SPREETAIL 1847864 · TMA1072236 | Spreetail, LLC | 35 Advertising | Registered | 2020 |
| SPORTEDGE 1677513 · TMA917433 | Eddie Bauer Licensing Services LLC | 25 Clothing | Registered | 2015 |
| Spartadia 1607266 · TMA885727 | an individual | 35 Advertising | Registered | 2014 |
| SPREETAIL 2245430 | Spreetail, LLC | 35 Advertising39 Transport | Pending | 2023 |
| SPROUT 2326778 · TMA1267581 | THOR TECH, INC. | 12 Vehicles | Registered | 2024 |
| SPORTGEAR 2258981 · TMA1277830 · design | an individual | 25 Clothing | Registered | 2024 |
| speroto 2253896 · TMA1272989 | Hangzhou Yinan Technology Co. Ltd. | 14 Jewellery | Registered | 2024 |
| Shopperations 2245645 · TMA1264469 | Shopperations Research & Technology, LLC | 35 Advertising42 Science | Registered | 2024 |
| SPREADSHOP 2243872 · TMA1183276 | Owner not shown | 35 Advertising38 Telecommunications40 Treatment+1 | Registered | 2023 |