| SPRUCE 2049709 · TMA1166744 | WestRock Shared Services, LLC, a legal entity | 16 Paper | Registered | 2023 |
| SPRUCE 1896818 · TMA1086877 | ECI Software Solutions, Inc. | 9 Electronics42 Science | Registered | 2020 |
| SPRUCE 1713458 · TMA946985 · design | OncoGenex Pharmaceuticals, Inc. | 42 Science44 Medical | Registered | 2016 |
| Spruce 1622781 · TMA890412 | OncoGenex Pharmaceuticals, Inc. | 35 Advertising38 Telecommunications42 Science+1 | Registered | 2014 |
| SPRUCE 2189496 | Targus International LLC | 9 Electronics18 Leather | Pending | 2022 |
| SPRUCE 2055837 | David S. McDonald Professional Corporation | 44 Medical | Pending | 2020 |
| SPRUCELAND 0897816 · TMA531081 | Millar Western Forest Products Ltd. | 19 Building | Registered | 2000 |
| SPRIG 2189910 · TMA1233648 | KOHLER CO. | 4 Oils | Registered | 2024 |
| SPRIG 2129317 · TMA1213065 · design | INTERGROW BRANDS PRIVATE LIMITED | 30 Coffee | Registered | 2023 |
| Spraxie 2117853 · TMA1195593 | 1275804 B.C. LTD. | 21 Housewares | Registered | 2023 |
| SPRIG 2082905 · TMA1224231 | KOHLER CO. | 3 Cosmetics11 Lighting | Registered | 2024 |
| SPRAYIQ 2039992 · TMA1199842 | Chem-Trend Limited Partnership | 9 Electronics42 Science | Registered | 2023 |
| SPRIG 1718014 · TMA1051595 | Posy, LLC | 32 Beer | Registered | 2019 |
| SPRYCEL 1386202 · TMA793356 · design | Bristol-Myers Squibb Holdings Ireland Unlimited Company | 16 Paper | Registered | 2011 |
| SPRYCEL 1308506 · TMA759905 · design | Bristol-Myers Squibb Holdings Ireland Unlimited Company | 5 Pharmaceuticals | Registered | 2010 |
| SPRYCEL 1274464 · TMA705587 | Bristol-Myers Squibb Holdings Ireland Unlimited Company | 5 Pharmaceuticals | Registered | 2008 |
| SPRIX 2300543 | Owner not listed | 9 Electronics16 Paper41 Education | Pending | 2023 |
| SPRIX 2174322 · design | Sprix, Ltd. | 9 Electronics16 Paper41 Education | Pending | 2022 |
| SPRIG 2134579 | Sprig Technologies Inc. | 9 Electronics35 Advertising38 Telecommunications+1 | Pending | 2021 |
| SPARKLING 1343356 · TMA765535 · design | MITSUBISHI PENCIL CO. LTD. | 16 Paper | Registered | 2010 |
| SPROCKIDS 1049289 · TMA554667 | Giant Bicycle, Inc. | 9 Electronics16 Paper25 Clothing+1 | Registered | 2001 |
| SUPERGAIN 0379584 · TMA214814 | Canada Bread Company, Limited | 30 Coffee | Registered | 1976 |
| SUPERSKIN 2162744 | Sled Distribution, LLC | 5 Pharmaceuticals10 Medical | Pending | 2022 |
| SVIRG 2297090 · TMA1283527 | 9504-8807 Québec Inc. | 25 Clothing | Registered | 2025 |
| SUPERSPARK 2270850 · TMA1264600 | L'OREAL | 21 Housewares | Registered | 2024 |